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26 p, 2.2 MB |
Inherited human ezrin deficiency impairs adaptive immunity
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García-Solís, Blanca (Hospital Universitario La Paz (Madrid)) ;
Van Den Rym, Ana (Hospital Universitario La Paz (Madrid)) ;
Martinez-Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Franco-Leyva, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-Caraballo, Jareb J. (Vanderbilt University Medical Center) ;
Markle, Janet (Vanderbilt University Medical Center) ;
Cubillos-Zapata, Carolina (Centre for Biomedical Research Network) ;
Marín, Ana V. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Recio, María J. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Regueiro, José R. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Navarro-Zapata, Alfonso (Hospital Universitario La Paz (Madrid)) ;
Mestre-Durín, Carmen (Hospital Universitario La Paz (Madrid)) ;
Ferreras, Cristina (Hospital Universitario La Paz (Madrid)) ;
Cotázar, Carla Martín (Hospital Universitario La Paz (Madrid)) ;
Mena, Roció (Hospital Universitario La Paz (Madrid)) ;
de la Calle-Fabregat, Carlos (Institut d'Investigació contra la Leucèmia Josep Carreras) ;
López-Lera, Alberto (Hospital Universitario La Paz (Madrid)) ;
Arquero, Miguel Fernández (Hospital Clínico San Carlos (Madrid)) ;
Pérez-Martínez, Antonio (Hospital Universitario La Paz (Madrid)) ;
López-Collazo, Eduardo (Hospital Universitario La Paz (Madrid)) ;
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos (Madrid)) ;
Casanova, Jean-Laurent (Howard Hughes Medical Institute) ;
Martínez-Barricarte, Rubén (Vanderbilt University Medical Center) ;
de la Calle-Martín, Oscar (Institut d'Investigació Biomèdica Sant Pau) ;
de Diego, Rebeca Pérez (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
Inborn errors of immunity (IEI) are a group of monogenic diseases that confer susceptibility to infection, autoimmunity, and cancer. Despite the life-threatening consequences of some IEI, their genetic cause remains unknown in many patients. [...]
2023 -  10.1016/j.jaci.2023.05.022
The Journal of Allergy and Clinical Immunology, Vol. 152 (june 2023) , p. 997-1009.e11
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6 p, 377.9 KB |
Clinical and genetic differences between pustular psoriasis subtypes
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Twelves, Sophie (King's College London) ;
Mostafa, Alshimaa (Beni Suef University) ;
Dand, Nick (King's College London) ;
Burri, Elias (University Hospital Zurich (Suïssa)) ;
Farkas, K. (University of Szeged) ;
Wilson, Rosemary (King's College London) ;
Cooper, Hywel L. (Portsmouth Hospitals Trust) ;
Irvine, Alan D. (Trinity College Dublin) ;
Oon, Hazel H. (National Skin Centre) ;
Kingo, Külli (Tartu University Hospital (Tartu, Estònia)) ;
Köks, Sulev (University of Tartu) ;
Mrowietz, Ulrich (University Medical Center Schleswig-Holstein) ;
Puig Sanz, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Reynolds, Nick (Newcastle Hospitals NHS Foundation Trust) ;
Tan, Euegene Sern-Ting (National Skin Centre) ;
Tanew, Adrian (Medical University of Vienna) ;
Torz, Kaspar (Campus Kiel) ;
Trattner, Hannes (Medical University of Vienna) ;
Valentine, Mark (University of Washington School of Medicine) ;
Wahie, Shyamal (University Hospital of North Durham and Darlington Memorial Hospital) ;
Warren, Richard B. (University of Manchester and the Academic Health Science Centre) ;
Wright, Andrew (St University of Bradford) ;
Bata-Csörgő, Zsuzsa (University of Szeged) ;
Szell, Marta (University of Szeged) ;
Griffiths, Christopher E.M. (University of Manchester and the Academic Health Science Centre) ;
Burden, A.David (University of Glasgow) ;
Choon, Siew-Eng (Monash University Malaysia) ;
Smith, Catherine H. (King's College London) ;
Barker, Jonathan N. (King's College London) ;
Navarini, Alexander A. (University Hospital Zurich (Suïssa)) ;
Capon, Francesca (King's College London) ;
Universitat Autònoma de Barcelona
The term pustular psoriasis indicates a group of severe skin disorders characterized by eruptions of neutrophil-filled pustules. The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis [PPP] and acrodermatitis continua of Hallopeau [ACH]) presentation. [...]
2019 - 10.1016/j.jaci.2018.06.038
The Journal of Allergy and Clinical Immunology, Vol. 143 Núm. 3 (march 2019) , p. 1021-1026
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3.
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23 p, 3.1 MB |
Short-Acting Beta-2-Agonist Exposure and Severe Asthma Exacerbations : SABINA Findings From Europe and North America
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Quint, Jennifer K. (Imperial College London) ;
Arnetorp, Sofie (Payer Analytics. AstraZeneca) ;
Kocks, Janwillem W.H. (University Medical Center Groningen) ;
Kupczyk, Maciej (Karolinska Institutet (Estocolm, Suècia)) ;
Nuevo, Javier (Evidence Generation. AstraZeneca) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Cabrera, Claudia (BioPharmaceuticals Medical (Evidence). AstraZeneca) ;
Raherison-Semjen, Chantal (Bordeaux University) ;
Walker, Brandie (University of Calgary) ;
Penz, Erika (University of Saskatchewan) ;
Gilbert, Ileen (Medical Affairs. AstraZeneca) ;
Lugogo, Njira Lucia (University of Michigan) ;
van der Valk, Ralf J.P. (Medical Affairs. AstraZeneca) ;
Fong, Andrew ;
Qian, Christina ;
Fabry-Vendrand, Caroline ;
Touboul, Chantal ;
Brzostek, Dorota ;
Maslova, Ekaterina ;
Surmont, Filip ;
Goike, Helena ;
Gandhi, Hitesh ;
Korevaar, J.C. ;
Tkacz, Joseph ;
Johnston, Karissa ;
Peres da Costa, Keith ;
van Dijk, L. ;
Vervloet, M. ;
Pollack, Michael ;
Hernandez, Paul ;
Boarino, S. ;
Noorduyn, Stephen G. ;
Beekman-Hendricks, Wendy ;
Weesie, Y.M. ;
Universitat Autònoma de Barcelona
Expert national/global asthma management recommendations raise the issue whether a safe threshold of short-acting beta-2 agonist (SABA) use without concomitant inhaled corticosteroids (ICS) exists. To examine SABA and maintenance therapy associations with severe asthma exacerbations across North America and Europe. [...]
2022 - 10.1016/j.jaip.2022.02.047
Journal of Allergy and Clinical Immunology: In Practice, Vol. 10 Núm. 9 (september 2022) , p. 2297-2309.e10
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9 p, 397.0 KB |
Determinants and Differences in Satisfaction with the Inhaler Among Patients with Asthma or COPD
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Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Giner, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Curto Sánchez, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso-Ortiz, M. Belén (Hospital Universitario de Gran Canaria Doctor Negrín Las Palmas de Gran Canaria) ;
Orue, Miren Itxaso (Centro de Salud Javier Sáenz de Buruaga (Bilbao, País Basc)) ;
Vega, José María (Hospital Regional Universitario de Málaga (Màlaga, Andalusia)) ;
Cosio, Borja G. (Institut d'Investigació Sanitària Illes Balears (Mallorca, Balears)) ;
Bellido Linares, Virginia (Hospital Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Mora, Roberto Bernabeu (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Cabrera César, Eva (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Callero Viera, Ariel (Hospital Universitario Ntra. Sra.de Candelaria (Santa Cruz de Tenerife)) ;
Castillo, Rafael (Hospital de Llíria) ;
Delgado Romero, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
de los Monteros-Garde, Mª José Espinosa (Hospital Virgen de la Salud) ;
Fernández Rodríguez-Lacín, José María (Centro de Salud Nata-hoyo) ;
García Robaina, José Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Hernández Gil, Aníbal Manuel (Hospital Comarcal de Laredo) ;
Hernández Rey, José Miguel (Hospital Punta de Europa) ;
Santana, Guacimara Hernández (Hospital Punta de Europa) ;
López Ruiz, Cristina (Hospital Universitari Vall d'Hebron) ;
Balaguer, Enrique Mascaros (Centro de Salud Fuente San Luis) ;
Mazo Echaniz, Francisco Javier (Hospital de Basurto (Bilbao, Biscaia)) ;
Moreno Pérez, Núria (Hospital Universitari Vall d'Hebron) ;
Arrondo, Antoni Parra (Hospital Abente y Lago) ;
Sánchez, José Portillo (Hospital General Universitario de Ciudad Real) ;
Rodríguez Encinar, José Ramón (Centro de Salud Arroyo de la Media Legua) ;
Rodríguez Plata, Elena (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Román Bernal, Berta (Hospital Dr. José Molina Osora) ;
Cunill Sala, Anna (Hospital Universitari Vall d'Hebron) ;
Sánchez Lora, Fernando J. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Sánchez Nieto, Juan Miguel (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Serra Batlles, Joan (Hospital Universitari de Vic) ;
Torres Relucio, José Joaquín (Hospital General Universitari de Castelló (País Valencià)) ;
Valido Morales, Agustín S. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Vázquez Alarcón, Rubén Luciano (Centro de Salud VERA) ;
Velasco Garrido, José Luis (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Universitat Autònoma de Barcelona
Satisfaction with the inhaler is an important determinant of treatment adherence in patients with asthma and chronic obstructive pulmonary disease (COPD). However, few studies have compared these 2 groups to identify the factors associated with satisfaction with the inhaler. [...]
2020 - 10.1016/j.jaip.2019.09.020
Journal of Allergy and Clinical Immunology: In Practice, Vol. 8 Núm. 2 (february 2020) , p. 645-653
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19 p, 3.2 MB |
Hematopoietic cell transplantation in severe combined immunodeficiency : The SCETIDE 2006-2014 European cohort
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Lankester, Arjan C. (Pediatric Stem Cell Transplantation Program and Laboratory for Pediatric Immunology. Willem-Alexander Children's Hospital. Leiden University Medical Center) ;
Neven, Benedicte (Institut Imagine. INSERM UMR1163. Laboratory of Immunogenetics of Pediatric Autoimmune Diseases) ;
Mahlaoui, Nizar (French National Reference Center for Primary Immunodeficiencies (CEREDIH) and European Registry for Stem Cell Transplantation for Primary Immunodeficiencies (SCETIDE). Hôpital Universitaire Necker-Enfants malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
von Asmuth, Erik G.J. (Pediatric Stem Cell Transplantation Program and Laboratory for Pediatric Immunology. Willem-Alexander Children's Hospital. Leiden University Medical Center) ;
Courteille, Virginie (French National Reference Center for Primary Immunodeficiencies (CEREDIH) and European Registry for Stem Cell Transplantation for Primary Immunodeficiencies (SCETIDE). Hôpital Universitaire Necker-Enfants malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
Alligon, Mikael (French National Reference Center for Primary Immunodeficiencies (CEREDIH) and European Registry for Stem Cell Transplantation for Primary Immunodeficiencies (SCETIDE). Hôpital Universitaire Necker-Enfants malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
Albert, Michael H. (Dr von Haunersches University Children's Hospital) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Bader, Peter (Department for Children and Adolescents Medicine. Division for Stem Cell Transplantation and Immunology. University Hospital Frankfurt) ;
Balashov, Dmitry (Department for Hematopoietic Stem Cell Transplantation. Dmitriy Rogachev National Center for Pediatric Hematology. Oncology and Immunology) ;
Beier, Rita (Klinik für Pädiatrische Hämatologie und Onkologie. Hannover Medical School) ;
Bertrand, Yves (Institut d'Hématologie et d'Oncologie Pédiatrique. Hospices Civils de Lyon and Université Claude Bernard Lyon 1) ;
Blanche, Stephane (Unité d'Immuno-hematologie et Rhumatologie Pédiatrique. Hôpital Universitaire Necker-Enfants Malades. Assistance Publique-Hôpitaux de Paris (AP-HP)) ;
Bordon, Victoria (Department of Pediatric Hemato-oncology and Stem Cell Transplant. Ghent University Hospital) ;
Bredius, Robert G. (Pediatric Stem Cell Transplantation Program and Laboratory for Pediatric Immunology. Willem-Alexander Children's Hospital. Leiden University Medical Center) ;
Cant, Andrew (Translational and Clinical Research Institute. Newcastle University. and the Paediatric Haematopoietic Stem Cell Transplant Unit. Great North Children's Hospital) ;
Cavazzana, Marina (Laboratory of Genomic Dynamics in the Immune System. Institut Imagine. INSERM UMR1163) ;
Díaz de Heredia, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Dogu, Figen (Department of PIA and the BMT Unit. Ankara University) ;
Ehlert, Karoline (Department of Pediatric Hematology and Oncology. University of Greifswald) ;
Entz-Werle, Natacha (Pediatric Onco-hematology Department-Pediatrics III. University Hospital of Strasbourg) ;
Fasth, Anders (Department of Pediatrics. Institute of Clinical Sciences. University of Gothenburg) ;
Ferrua, Francesca (Pediatric Immunohematology and Bone Marrow Transplantation Unit and the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget). IRCCS San Raffaele Scientific Institute) ;
Ferster, Alina (Department of Hemato-oncology. Hôpital Universitaire des Enfants Reine Fabiola) ;
Formankova, Renata (Department of Pediatric Hematology and Oncology. Teaching Hospital Motol. 2nd Medical School. Charles University Motol) ;
Friedrich, Wilhelm (Department of Pediatrics. University Medical Center Ulm) ;
Gonzalez-Vicent, Marta (Hospital del Niño Jesús. Hematopoietic Stem Cell Transplantation and Cellular Therapy Unit) ;
Gozdzik, Jolanta (Department of Clinical Immunology and Transplantation. Jagiellonian University Medical College) ;
Güngör, Tayfun (Department of Hematology. Oncology. Immunology. Gene Therapy and Stem Cell Transplantation. and Children's Research Center (CRC). University Children's Hospital) ;
Hoenig, Manfred (Department of Pediatrics. University Medical Center Ulm) ;
Ikinciogullari, Aydan (Department of PIA and the BMT Unit. Ankara University) ;
Kalwak, Krzysztof (Department of Pediatric Hematology. Oncology. and BMT. Wroclaw Medical University) ;
Kansoy, Savas (Department of Pediatric Hematology and Oncology. Ege University Hospital) ;
Kupesiz, Alphan (Department of Pediatrics. Hematology. and Oncology. Akdeniz University School of Medicine) ;
Lanfranchi, Arnalda (Diagnostic Department. Stem Cell Laboratory. Section of Hematology and Blood Coagulation. Clinical Chemistry Laboratory. ASST Spedali Civili) ;
Lindemans, Caroline A. (Department of Pediatrics. University Medical Center Utrecht. University of Utrecht) ;
Meisel, Roland (Department of Pediatric Oncology. Hematology. and Clinical Immunology. Medical Faculty. Division of Pediatric Stem Cell Therapy. Heinrich-Heine-University) ;
Michel, Gerard (Service d'Hématologie Immunologie Oncologie Pédiatrique. CHU La Timone) ;
Miranda, Nuno A. A. (BMT Unit. Instituto Português de Oncologia de Lisboa) ;
Moraleda, Jose (Instituto Murciano de Investigación Biosanitaria) ;
Moshous, Despina (Laboratory of Genomic Dynamics in the Immune System. Institut Imagine. INSERM UMR1163) ;
Pichler, Herbert (Department of Stem Cell Transplantation. Children's Cancer Institute. St Anna Hospital) ;
Rao, Kanchan (Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust and University College London GOS Institute of Child Health) ;
Sedlacek, Petr (Department of Pediatric Hematology and Oncology. Teaching Hospital Motol. 2nd Medical School. Charles University Motol) ;
Slatter, Mary (Translational and Clinical Research Institute. Newcastle University. and the Paediatric Haematopoietic Stem Cell Transplant Unit. Great North Children's Hospital) ;
Soncini, Elena (Pediatric Oncohaematology and BMT Unit. Children's Hospital Brescia) ;
Speckmann, Carsten (Department of Pediatric Hematology and Oncology. Center for Pediatrics and Adolescent Medicine. Institute for Immunodeficiency. Center for Chronic Immunodeficiency (CCI). Faculty of Medicine. Medical Center. University of Freiburg) ;
Sundin, Mikael (Section of Pediatric Hematology. Immunology. and HCT. Astrid Lindgren Children's Hospital. Karolinska University Hospital. and Division of Pediatrics. CLINTEC. Karolinska Institutet) ;
Toren, Amos (Paediatric Hemato-oncology and BMT. Sheba Medical Center) ;
Vettenranta, Kim (University of Helsinki and Children's Hospital. University of Helsinki) ;
Worth, Austen (Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust and University College London GOS Institute of Child Health) ;
Yeşilipek, Mehmet A. (Pediatric Hematology. Oncology. and Pediatric Stem Cell Transplantation Unit. Medicalpark Antalya & Göztepe Hospitals) ;
Zecca, Marco (Pediatric Hematology/Oncology. Fondazione IRCCS Policlinico San Matteo) ;
Porta, Fulvio (Pediatric Oncohaematology and BMT Unit. Children's Hospital Brescia) ;
Schulz, Ansgar (Department of Pediatrics. University Medical Center Ulm) ;
Veys, Paul (Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust and University College London GOS Institute of Child Health) ;
Fischer, Alain (Université de Paris) ;
Gennery, Andrew R. (Translational and Clinical Research Institute. Newcastle University. and the Paediatric Haematopoietic Stem Cell Transplant Unit. Great North Children's Hospital)
Background: Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), a group of monogenic immune disorders with an otherwise fatal outcome. [...]
2022 - 10.1016/j.jaci.2021.10.017
The Journal of Allergy and Clinical Immunology, Vol. 149 Núm. 5 (may 2022) , p. 1744-1754.e8
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11 p, 1.9 MB |
The ATLAS ASMA Study : Assessing the Impact of Asthma on Patients' Life - The Spanish Patients' Perspective
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Domínguez-Ortega, Javier (Hospital Universitario La Paz (Madrid)) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Nieto Garcíá, Antonio (Instituto de Investigación Sanitaria La Fe) ;
Delgado Romero, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Ancochea, Julio (Instituto de Salud Carlos III) ;
Mejia, Natalia (Novartis Farmacéutica) ;
Pastor, Mariano (Fundación Española de Asociaciones de Pacientes Alérgicos y con Enfermedades Respiratorias) ;
Blanco-Aparicio, Marina (Complejo Hospitalario Universitario de A Coruña) ;
Universitat Autònoma de Barcelona
ATLAS ASMA described the psychosocial impact of asthma on patients' daily life from patients' perspectives (in terms of impaired personal and intimate relationships, sleep quality, leisure time, daily activities, and others) in Spain. [...]
2023 - 10.2147/JAA.S404525
Journal of Asthma and Allergy, Vol. 16 (may 2023) , p. 461-471
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4 p, 302.7 KB |
Improvement in Lung Function with Dupilumab Does Not Predict Its Effects on Reducing Asthma Exacerbation
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Hanania, Nicola A (Baylor College of Medicine) ;
Maspero, Jorge F (Fundación CIDEA) ;
Halpin, David M G (University of Exeter) ;
Jackson, David J (Guy's Severe Asthma Centre, Guy's and St Thomas' NHS Foundation Trust) ;
Panettieri, Reynold A (The State University of New Jersey) ;
Castro, Mario (University of Kansas School of Medicine) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Daizadeh, Nadia (Sanofi) ;
Gall, Rebecca (Regeneron Pharmaceuticals. Inc) ;
Jacob-Nara, Juby A (Sanofi) ;
Ortiz, Benjamin (Regeneron Pharmaceuticals. Inc) ;
Djandji, Michel (Sanofi) ;
Rowe, Paul J (Sanofi) ;
Deniz, Yamo (Regeneron Pharmaceuticals. Inc) ;
Universitat Autònoma de Barcelona
2022 - 10.2147/JAA.S354013
Journal of Asthma and Allergy, Vol. 15 (june 2022) , p. 851-854
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0 p, 691.1 KB |
Curation and expansion of Human Phenotype Ontology for defined groups of inborn errors of immunity
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Haimel, Matthias (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Pazmandi, Julia (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Heredia, Raú Jiménez (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Dmytrus, Jasmin (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Bal, Sevgi Köstel (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
Zoghi, Samaneh (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (Vienna)) ;
van Daele, Paul (Erasmus University Medical Center (Rotterdam)) ;
Briggs, Tracy A. (University of Manchester) ;
Wouters, Carine (University Hospitals Leuven (Bèlgica)) ;
Bader-Meunier, Brigitte (Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE) (Paris)) ;
Aeschlimann, Florence A. (Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE),(Paris)) ;
Caorsi, Roberta (IRCCS Istituto Giannina Gaslini, Genova) ;
Eleftheriou, Despina (Hospital for Children NHS Foundation Trust (London)) ;
Hoppenreijs, Esther (Radboud University Medical Centre (Nijmegen)) ;
Salzer, Elisabeth (Medical University of Vienna) ;
Bakhtiar, Shahrzad (Goethe University) ;
Derfalvi, Beata (Dalhousie University/IWK Health Centre Halifax) ;
Saettini, Francesco (University of Milano Bicocca) ;
Kusters, Maaike A. A. (Hospital for Children NHS Foundation Trust) ;
Elfeky, Reem (Hospital for Children NHS Foundation Trust (London)) ;
Trück, Johannes (University Children's Hospital Zurich) ;
Rivière, Jacques G.. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van der Burg, Mirjam (Leiden University Medical Center) ;
Gattorno, Marco (IRCCS Istituto Giannina Gaslini (Genova)) ;
Seidel, Markus G. (Medical University Graz) ;
Burns, Siobhan (Royal Free Hospital NHS Foundation Trust) ;
Warnatz, Klaus (University of Freiburg) ;
Hauck, Fabian (Ludwig-Maximilians-Universität München (Munich)) ;
Brogan, Paul (Hospital for Children NHS Foundation Trust (London)) ;
Gilmour, Kimberly C. (Hospital for Children NHS Foundation Trust (London)) ;
Schuetz, Catharina (Technische Universität Dresden) ;
Simon, Anna (Radboud University Nijmegen Medical Centre) ;
Bock, Christoph (Medical University of Vienna) ;
Hambleton, Sophie (Newcastle University) ;
de Vries, Esther (Elisabeth-Tweesteden Hospital (Tilburg)) ;
Robinson, Peter N. (The Jackson Laboratory for Genomic Medicine (Farmington)) ;
van Gijn, Marielle (University Medical Center Groningen) ;
Boztug, Kaan (Medical University of Vienna) ;
Universitat Autònoma de Barcelona
Accurate, detailed, and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. [...]
2021 - 10.1016/j.jaci.2021.04.033
The Journal of Allergy and Clinical Immunology, Vol. 149 (may 2021) , p. 369-378
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7 p, 1.3 MB |
The Response to Biologics is Better in Patients with Severe Asthma Than in Patients with Asthma-COPD Overlap Syndrome
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Pérez de Llano, Luis (Pneumology Service. Hospital Lucus Augusti. EOXI Lugo. Cervo e Monforte) ;
Dacal Rivas, David (Hospital Universitario Lucus Augusti (Lugo)) ;
Malanda, Nuria Marina (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Gullón, José Antonio (Hospital Universitario Lucus Augusti (Lugo)) ;
Muñoz-Esquerre, Mariana (Institut d'Investigació Biomèdica de Bellvitge) ;
García-Moguel, Ismael (Allergy Service) ;
Díaz Campos, Rocío Magdalena (Hospital Universitario) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
Harbenau Mena, Alicia (Hospital de Mérida) ;
Cosio, Borja G (Institut d’Investigació Sanitària Illes Balears) ;
Padilla, Alicia (Hospital Costa del Sol (Marbella)) ;
Cisneros, Carolina (Hospital Universitario de la Princesa (Madrid))
Although biologics have demonstrated to be effective in T2-high asthma patients, there is little experience with these drugs in asthma-COPD overlap (ACO). The aim of this study was to compare the effectiveness of biologics in these two conditions. [...]
2022 - 10.2147/JAA.S338467
Journal of Asthma and Allergy, Vol. 15 (2022) , p. 363-369
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9 p, 430.4 KB |
Dupilumab Efficacy in Steroid-Dependent Severe Asthma by Baseline Oral Corticosteroid Dose
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Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Maspero, Jorge F (Fundación CIDEA) ;
Castro, Mario (University of Kansas School of Medicine) ;
Hanania, Nicola A. (Baylor College of Medicine) ;
Ford, Linda B (Asthma & Allergy Center) ;
Halpin, David M G (College of Medicine and Health) ;
Jackson, David J (King's College London) ;
Daizadeh, Nadia (Sanofi-Syntelabo) ;
Djandji, Michel (Sanofi-Syntelabo) ;
Mitchell, Colin P (Sanofi-Syntelabo) ;
Crikelair, Nora (Regeneron Pharmaceuticals. Inc) ;
Jacob-Nara, Juby A (Sanofi-Syntelabo) ;
Deniz, Yamo (Regeneron Pharmaceuticals. Inc) ;
Rowe, Paul J (Sanofi-Syntelabo) ;
Ortiz, Benjamin (Regeneron Pharmaceuticals. Inc) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4/-13, key and central drivers of type 2 inflammation in multiple diseases. In the phase 3 LIBERTY ASTHMA VENTURE (VENTURE) study (NCT02528214), dupilumab versus placebo reduced oral corticosteroid (OCS) dose and improved clinical outcomes in patients with OCS-dependent severe asthma. [...]
2022 - 10.1016/j.jaip.2022.03.020
The Journal of allergy and clinical immunology. In practice, Vol. 10 Núm. 7 (July 2022) , p. 1835-1843
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